Comparison of the SuperARMS and Droplet Digital PCR for Detecting EGFR Mutation in ctDNA From NSCLC Patients
Wei-neng Feng, Wei-quan Gu, Ning Zhao, et al.

Super-ARMS and ddPCR share the similar accuracy for EGFR mutation detection in plasma biopsy; both methods predicted well the efficacy of EGFR-TKIs by detecting plasma EGFR status.

Translational Oncology (2018) 11, 542–545

Detection of EGFR mutations in plasma circulating tumour DNA as a selection criterion for frst-line geftinib treatment in patients with advanced lung adenocarcinoma (BENEFIT): a phase 2, single-arm, multicentre clinical trial
Zhijie Wang, Ying Cheng, Tongtong An, et al.

Detection of EGFR mutations in ctDNA is an effective method to identify patients who might beneft from frst-line geftinib treatment. Further analyses of dynamic alterations of EGFR mutations and accompanying gene aberrances could predict resistance to geftinib.

www.thelancet.com/respiratory Published online July 12, 2018 http://dx.doi.org/10.1016/S2213-2600(18)30264-9

Use of SuperARMS EGFR Mutation Detection Kit to Detect EGFR in Plasma Cell-free DNA of Patients With Lung Adenocarcinoma
Shaohua Cui, Lin Ye, Huimin Wang, et al.

SuperARMS is a promising plasma-based assay for EGFR mutations, including T790M. It might be useful in advanced-stage lung adenocarcinoma patients whose tissue biopsy samples are insufficient for a traditional diagnostic EGFR assay or for patients with a poor performance status.

Clinical Lung Cancer, 2017. https://doi.org/10.1016/j.cllc.2017.12.009

Comparison of the Amplification Refractory Mutation System, Super Amplification Refractory Mutation System, and Droplet Digital PCR for T790M Mutation Detection in Non-small Cell Lung Cancer after Failure of Tyrosine Kinase Inhibitor Treatment
Lucheng Zhu, Shirong Zhang, Yanping Xun, et al.

In conclusion, the results from this prospective study indicated the important clinical impact of T790 M detection using plasma samples for NSCLC patients who failed after EGFR-TKI therapy. Well concordance among three assays indicated the feasibility of plasma ctDNA detection. The ddPCR assay had a high sensitivity and might be superior to ARMS and SuperARMS assays.

Pathol. Oncol. Res., 2017. DOI 10.1007/s12253-017-0286-3

Clinical validation of a highly sensitive assay to detect EGFR mutations in plasma cell-free DNA from patients with advanced lung adenocarcinoma
Yuping Li, Hanyan Xu, Shanshan Su, et al.

ADx-SuperARMS EGFR assay is likely to be a highly sensitive and specific method to noninvasively detect plasma EGFR mutations of patients with advanced lung adenocarcinoma. The EGFR mutations detected by ADx-SuperARMS EGFR assay could predict the efficacy of the treatment with first generation of EGFR-TKIs. Hence, EGFR blood testing with ADxSuperARMS could address the unmet clinical needs.

PLOS ONE, August 22, 2017. https://doi.org/10.1371/journal.pone.0183331.

Feasibility of cytological specimens for ALK fusion detection in patients with advanced NSCLC using the method of RT-PCR
Yan Wang, Yu Liu, Chao Zhao, et al.

Histological tissues are preferred for anaplastic lymphoma kinase(ALK)  fusion detection in non-small cell lung cancer(NSCLC). The aim of this study was to evaluate the feasibility of cytological sample as an alternative specimen for ALK fusion  testing in patients with advanced NSCLC. 
 

LUNG CANCER, DOI: http://dx.doi.org/doi:10.1016/j.lungcan. 2016.01.014

腾讯分分彩怎么稳赚不赔 陆河县| 岳阳县| 法库县| 吉林省| 溧水县| 苍溪县| 巴彦淖尔市| 德昌县| 汶上县| 乡宁县| 长岭县| 龙里县| 略阳县| 深水埗区| 黄大仙区| 共和县| 无极县| 太白县| 育儿| 盐津县| 宝鸡市| 奈曼旗| 北流市| 和静县| 类乌齐县| 库伦旗| 曲沃县| 根河市| 阳西县| 开阳县| 龙井市| 虞城县| 体育| 肃北| 呼伦贝尔市| 乐清市| 黑龙江省| 焦作市| 萝北县| 永寿县| 铜川市| 阿坝| 安远县| 普宁市| 福海县| 桐乡市| 乌兰县| 喀什市| 淅川县| 临沭县| 武邑县| 沐川县| 民丰县| 通许县| 高密市| 宜良县| 喜德县| 明水县| 沅江市| 扶绥县| 罗城| 广南县| 正镶白旗| 南雄市| 昌宁县| 神木县| 凌源市| 惠来县| 裕民县| 剑阁县| 绍兴市| 黑山县| 衡东县| 昆山市| 赤城县| 湘阴县| 宝山区| 凌源市| 池州市| 湖州市| 溆浦县| 吉安县| 吴桥县| 美姑县| 金乡县| 饶河县| 航空| 阳谷县| 桂东县| 芜湖县| 友谊县| 潢川县| 苏尼特右旗| 东兴市| 河池市| 邓州市| 双辽市| 屏东县| 来安县| 华池县| 保亭| 博客| 太湖县| 筠连县| 阿拉尔市| 静宁县| 福安市| 浦江县| 三台县| 金门县| 望谟县| 丹阳市| 德昌县| 义乌市| 红原县| 兴隆县| 崇文区| 西林县| 西畴县| 板桥市| 固始县| 日喀则市| 山西省| 贵定县| 徐闻县| 长丰县| 增城市| 新和县| 蒙自县| 静安区| 梁山县| 东安县| 沁阳市| 绥滨县| 措美县| 英超| 宁海县|